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KMID : 0043320050280111251
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Archives of Pharmacal Research
2005 Volume.28 No. 11 p.1251 ~ p.1256
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Cytoprotective Effect of Green Tea Extract and Quercetin against Hydrogen Peroxide-Induced Oxidative Stress
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Jung Yun-Mi
Choi Yeong-Gon
Kim Dong-Seok
Park Seo-Hyoung
Yoon Jin-A
Kwon Sun-Bang
Park Eun-Sang
Park Kyoung-Chan
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Abstract
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In this study, we evaluated the cytoprotective effects of antioxidative substances in hydrogen peroxide () treated Mel-Ab melanocytes. Tested substances include selenium, quercetin, green tea (GT) extract, and several vitamins (ascorbic acid, Trolox, and folic acid). Of these, both quercetin and GT extract were found to have strong cytoprotective effects on induced cell death. We also examined additive effects, but no combination of two of any of the above substances was found to act synergistically against oxidative damage in Mel-Ab cells. Nevertheless, a multi-combination of GT extract, quercetin, and folic acid appeared to prevent cellular damage in a synergistic manner, which suggests that combinations of antioxidants may be of importance, and that co-treatment with antioxidants offers a possible means of treating vitiligo, which is known to be related to melanocyte oxidative stress.
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KEYWORD
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Oxidative stress, Reactive oxygen species, Cytoprotection, Antioxidant, Vitiligo
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